Article
Secreted Frizzled-related protein 3 (sFRP3)-mediated suppression of interleukin-6 receptor release by A disintegrin and metalloprotease 17 (ADAM17) is abrogated in the osteoarthritis-associated rare double variant of sFRP3.
The Biochemical journal - 15 Jun 2015
Oldefest Mirja, Düsterhöft Stefan, Desel Christine, Thysen Sarah, Fink Christine, Rabe Björn, Lories Rik, Grötzinger Joachim, Lorenzen Inken
Abstract excerpt
To avoid malformation and disease, tissue development and homoeostasis are co-ordinated precisely in time and space. Secreted Frizzled-related protein 3 (sFRP3), encoded by the Frizzled-related protein gene (FRZB), acts as an antagonist of Wnt signalling in bone development by delaying the maturation of proliferative chondrocytes into hypertrophic chondrocytes. A disintegrin and metalloprotease 17 (ADAM17) is a...
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