Alternative splicing and proteolytic rupture contribute to the generation of soluble IL-6 receptors (sIL-6R) in rheumatoid arthritis.

doi:10.1016/j.cyto.2012.12.025

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Article

Alternative splicing and proteolytic rupture contribute to the generation of soluble IL-6 receptors (sIL-6R) in rheumatoid arthritis.

Cytokine - 1 Mar 2013

Lamas José Ramón, Rodríguez-Rodríguez Luis, Tornero-Esteban Pilar, Villafuertes Esther, Hoyas José, Abasolo Lydia, Varadé Jezabel, Alvarez-Lafuente Roberto, Urcelay Elena, Fernández-Gutiérrez Benjamín

Abstract excerpt

OBJECTIVE: To describe the relationship between the two mechanisms involved in sIL6R generation in rheumatoid arthritis (RA). METHOD: RA patients were selected from a group of subjects genotyped for the rs8192284 SNP, located at the proteolytic cleavage site of IL-6R. sIL6R and protease levels (ADAM17) were measured and the contribution of alternative splicing in the generation of sIL-6R was evaluated through...

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PMID: 23375120
DOI: 10.1016/j.cyto.2012.12.025

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ADAM17

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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