Article

An intron-based timer for circadian rhythms

2025-10-27

Abstract excerpt

Abstract: Circadian clocks regulate daily rhythms in all eukaryotes through ∼24-hour transcriptional-translational feedback loops driven by clock proteins. However, the molecular mechanisms that set the 24-hour period remain poorly defined. Here, using single-molecule imaging and nascent RNA sequencing, we uncover an unexpected RNA-based molecular timer: a single intron in the Drosophila timeless ( tim ) gene th...

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Literature Corpus work: eb276013-a5de-5908-9f67-fadee26bd5bb
DOI: 10.1101/2025.10.27.684876

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