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Article

Chemokine MCP1/CCL2 and RANTES/CCL5 gene polymorphisms influence Henoch-Schönlein purpura susceptibility and severity.

Journal of the Formosan Medical Association = Taiwan yi zhi - 1 Apr 2015

Yu Hsin-Hui, Liu Pi-Hua, Yang Yao-Hsu, Lee Jyh-Hong, Wang Li-Chieh, Chen Wei-J, Chiang Bor-Luen

Abstract excerpt

BACKGROUND/PURPOSE: Henoch-Schönlein purpura (HSP) is the most common small vessel vasculitis in children. It is considered to be an IgA-containing immune complex-mediated disease. Chemokines are small secreted proteins that attract leukocytes during inflammation. Our aim was to determine the serum levels of chemokines and investigate the association of chemokine gene polymorphisms with childhood HSP. METHODS:...

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Identifiers

PMID: 25839768
DOI: 10.1016/j.jfma.2012.12.007

Genes

CCL5
CCL2
CXCL10
CXCL8
CXCL9

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