Article
Effect of paraoxonase 1 gene polymorphisms on clinical course of Henoch-Schönlein purpura.
Journal of nephrology - 1 Jan 2000
Yilmaz Alev, Emre Sevinc, Agachan Bedia, Bilge Ilmay, Yilmaz Hulya, Ergen Arzu, Isbir Turgay, Sirin Aydan
Abstract excerpt
BACKGROUND: Henoch-Schönlein purpura (HSP) is a systemic vasculitis; its pathogenesis is still unknown. Oxidative stress may play a role in the pathogenesis of HSP. Paraoxonase1 (PON1) is an antioxidant enzyme. Two polymorphisms have been defined in the coding region of the PON1 gene, Q/R192 and...
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