Article
Next-generation sequencing reveals the biological significance of the N(2),3-ethenoguanine lesion in vivo.
Nucleic acids research - 23 Jun 2015
Chang Shiou-chi, Fedeles Bogdan I, Wu Jie, Delaney James C, Li Deyu, Zhao Linlin, Christov Plamen P, Yau Emily, Singh Vipender, Jost Marco, Drennan Catherine L, Marnett Lawrence J, Rizzo Carmelo J, Levine Stuart S, Guengerich F Peter, Essigmann John M
Abstract excerpt
Etheno DNA adducts are a prevalent type of DNA damage caused by vinyl chloride (VC) exposure and oxidative stress. Etheno adducts are mutagenic and may contribute to the initiation of several pathologies; thus, elucidating the pathways by which they induce cellular transformation is critical. Although N(2),3-ethenoguanine (N(2),3-εG) is the most abundant etheno adduct, its biological consequences have not been...
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