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Article

Formation of etheno adducts and their effects on DNA polymerases.

IARC scientific publications - 1 Jan 1999

Guengerich F P, Langouët S, Mican A N, Akasaka S, Müller M, Persmark M

Abstract excerpt

Etheno (epsilon) and related DNA adducts are formed from the reaction of certain bifunctional electrophiles with DNA. Our interest has been focused on oxiranes substituted with leaving groups, e.g. 2-chlorooxirane, the epoxide derived from the carcinogen vinyl chloride. The chemical mechanisms of the formation of the major etheno products derived from adenine, cytosine and guanine have been elucidated by nuclear...

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PMID: 10626215

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