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Article

Etheno adducts formed in DNA of vinyl chloride-exposed rats are highly persistent in liver.

Carcinogenesis - 1 Apr 1992

Swenberg J A, Fedtke N, Ciroussel F, Barbin A, Bartsch H

Abstract excerpt

Preweanling rats were exposed to 600 p.p.m. (4h/day) of the human carcinogen vinyl chloride for 5 days to determine the molecular dosimetry of DNA adducts in liver, lung and kidney. 7-(2'-Oxoethyl)guanine (7OEG) was the major DNA adduct detected, representing approximately 98% of all adducts. N2,3-Ethenoguanine (epsilon G) and 3,N4-etheno-2'-deoxycytidine (epsilon dC) were present at approximately 1% of the 7OEG...

Topics

Animals
DNA
Deoxyadenosines
Guanine
Liver
Mutation
Rats
Rats, Inbred Strains
Vinyl Chloride

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1576725
DOI: 10.1093/carcin/13.4.727

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1576725-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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