Article
PTEN Expression as a Predictor of Response to Focal Adhesion Kinase Inhibition in Uterine Cancer.
Molecular cancer therapeutics - 1 Jun 2015
Thanapprapasr Duangmani, Previs Rebecca A, Hu Wei, Ivan Cristina, Armaiz-Pena Guillermo N, Dorniak Piotr L, Hansen Jean M, Rupaimoole Rajesha, Huang Jie, Dalton Heather J, Ali-Fehmi Rouba, Coleman Robert L, Sood Anil K
Abstract excerpt
PTEN is known to be frequently mutated in uterine cancer and also dephosphorylates FAK. Here, we examined the impact of PTEN alterations on the response to treatment with a FAK inhibitor (GSK2256098). In vitro and in vivo therapeutic experiments were carried out using PTEN-mutated and PTEN-wild-type models of uterine cancer alone and in combination with chemotherapy. Treatment with GSK2256098 resulted in greater...
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