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Article

Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells.

International journal of oncology - 1 May 2004

St-Germain Marie-Eve, Gagnon Veronique, Mathieu Isabelle, Parent Sophie, Asselin Eric

Abstract excerpt

In human endometrial cancer, the fourth most common cancer in women, tumor suppressor phosphatase tensin homologue (PTEN) is frequently mutated. In the presence of a mutated PTEN protein, Akt phosphorylation levels are increased leading to the activation of this survival pathway. Numerous studies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15067356

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15067356-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells.PMID 15067356Read ↗

Regulation of COX-2 protein expression by Akt in endometrial cancer cells is mediated through NF-kappaB/IkappaB pathway.Semantic proximity Read ↗

Akt activity in endometrial cancer cells: regulation of cell survival through cIAP-1.Semantic proximity Read ↗

Growth suppression activity of the PTEN tumor suppressor gene in human endometrial cancer cells.Semantic proximity Read ↗

Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss.Semantic proximity Read ↗

Activation of PI3K/Akt/mTOR pathway and dual inhibitors of PI3K and mTOR in endometrial cancer.Semantic proximity Read ↗

Somatic mutations are present in all members of the AKT family in endometrial carcinomaSemantic proximity Read ↗

Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis.Semantic proximity Read ↗

PTEN Expression as a Predictor of Response to Focal Adhesion Kinase Inhibition in Uterine Cancer.Semantic proximity Read ↗

Inhibition of AKT survival pathway by a small molecule inhibitor in human endometrial cancer cells.Semantic proximity Read ↗

Expression, activation, and role of AKT isoforms in the uterusSemantic proximity Read ↗

Activated mutant p110α causes endometrial carcinoma in the setting of biallelic Pten deletion.Semantic proximity Read ↗

Molecular alterations of PI3K/Akt/mTOR pathway: a therapeutic target in endometrial cancer.Semantic proximity Read ↗

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