Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival.

The Journal of biological chemistry - 15 Jan 2010

Lim Ssang-Taek, Miller Nichol L G, Nam Ju-Ock, Chen Xiao Lei, Lim Yangmi, Schlaepfer David D

Abstract excerpt

Pyk2 is a cytoplasmic tyrosine kinase related to focal adhesion kinase (FAK). Compensatory Pyk2 expression occurs upon FAK loss in mice. However, the impact of Pyk2 up-regulation remains unclear. Previous studies showed that nuclear-localized FAK promotes cell proliferation and survival through FAK FERM domain-enhanced p53 tumor suppressor degradation (Lim, S. T., Chen, X. L., Lim, Y., Hanson, D. A., Vo, T. T.,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Bromodeoxyuridine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to Focal Adhesion Kinase 2

Share to Gene Knockdown Techniques

Share to Proto-Oncogene Proteins c-mdm2

Share to Staurosporine

Share to Stress, Physiological

Source

Open in PubMed Open full text

Identifiers

PMID: 19880522
DOI: 10.1074/jbc.M109.064212
PMCID: PMC2804332

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival.PMID 19880522Read ↗

Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development and TherapySemantic proximity Read ↗

Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer DevelopmentSemantic proximity Read ↗

MAP kinase ERK5 modulates cancer cell sensitivity to extrinsic apoptosis induced by death-receptor agonists and Natural Killer cellsSemantic proximity Read ↗

Proline-Rich Protein Tyrosine Kinase 2 in Inflammation and CancerSemantic proximity Read ↗

Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cellsSemantic proximity Read ↗

PTEN Expression as a Predictor of Response to Focal Adhesion Kinase Inhibition in Uterine Cancer.Semantic proximity Read ↗

Skp2 Inhibitors: Novel Anticancer StrategiesSemantic proximity Read ↗

Co-targeting of FAK and MDM2 triggers additive anti-proliferative effects in mesothelioma via a coordinated reactivation of p53.Semantic proximity Read ↗

The Pyk2 FERM regulates Pyk2 complex formation and phosphorylation.Semantic proximity Read ↗

p53-independent p21 induction by MELK inhibitionSemantic proximity Read ↗

Cytoplasmic p21 Mediates 5-Fluorouracil Resistance by Inhibiting Pro-Apoptotic Chk2Semantic proximity Read ↗

Skp2 regulates G2/M progression in a p53-dependent manner.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.