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Article

STAT3 and HIF1α Signaling Drives Oncogenic Cellular Phenotypes in Malignant Peripheral Nerve Sheath Tumors.

Molecular cancer research : MCR - 1 Jul 2015

Rad Ellie, Dodd Kayleigh, Thomas Laura, Upadhyaya Meena, Tee Andrew

Abstract excerpt

UNLABELLED: Therapeutic options are limited for neurofibromatosis type 1 (NF1)-associated malignant peripheral nerve sheath tumors (MPNST) and clinical trials using drug agents have so far been unsuccessful. This lack of clinical success is likely attributed to high levels of intratumoral molecular heterogeneity and variations in signal transduction within MPNSTs. To better explore the variance of malignant...

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Source

Identifiers

PMID: 25833823
DOI: 10.1158/1541-7786.MCR-14-0182

Genes

STAT3
MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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