Article
Activated MET is a molecular prognosticator and potential therapeutic target for malignant peripheral nerve sheath tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2011
Torres Keila E, Zhu Quan-Sheng, Bill Katelynn, Lopez Gonzalo, Ghadimi Markus P, Xie Xianbiao, Young Eric D, Liu Juehui, Nguyen Theresa, Bolshakov Svetlana, Belousov Roman, Wang Suizhau, Lahat Guy, Liu Jun, Hernandez Belinda, Lazar Alexander J, Lev Dina
Abstract excerpt
PURPOSE: MET signaling has been suggested a potential role in malignant peripheral nerve sheath tumors (MPNST). Here, MET function and blockade were preclinically assessed. EXPERIMENTAL DESIGN: Expression levels of MET, its ligand hepatocyte growth factor (HGF), and phosphorylated MET (pMET) were examined in a clinically annotated MPNST tissue microarray (TMA) incorporating univariable and multivariable...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.