Article
Very high levels of anti-citrullinated protein antibodies are associated with HLA-DRB1*15 non-shared epitope allele in patients with rheumatoid arthritis.
Arthritis and rheumatism - 1 Jul 2012
Laki Judit, Lundström Emeli, Snir Omri, Rönnelid Johan, Ganji Izabella, Catrina Anca I, Bengtsson Camilla, Saevarsdottir Saedis, Wick Marius C, Alfredsson Lars, Klareskog Lars, Padyukov Leonid
Abstract excerpt
OBJECTIVE: Production of anti-citrullinated protein antibodies (ACPAs) is an important biomarker for rheumatoid arthritis (RA). We undertook this study to determine whether genetic factors (HLA-DRB1 alleles) are associated with extreme ACPA levels in individuals with ACPA-positive RA, and to asce...
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