Article
A large-scale association study identified multiple HLA-DRB1 alleles associated with ACPA-negative rheumatoid arthritis in Japanese subjects.
Annals of the rheumatic diseases - 1 Dec 2011
Terao Chikashi, Ohmura Koichiro, Kochi Yuta, Ikari Katsunori, Maruya Etsuko, Katayama Masaki, Shimada Kota, Murasawa Akira, Honjo Shigeru, Takasugi Kiyoshi, Matsuo Keitaro, Tajima Kazuo, Suzuki Akari, Yamamoto Kazuhiko, Momohara Shigeki, Yamanaka Hisashi, Yamada Ryo, Saji Hiroo, Matsuda Fumihiko, Mimori Tsuneyo
Abstract excerpt
BACKGROUND: HLA-DRB1 is associated with rheumatoid arthritis (RA). However, it has recently been suggested that HLA-DRB1 is only associated with patients with RA who have anticitrullinated peptide/protein antibodies (ACPA), which are specific to RA. OBJECTIVE: To elucidate whether specific HLA-DR alleles are associated with ACPA-negative RA development. METHODS: HLA-DRB1 typing was carried out in 368 Japanese...
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