Article
Resistance studies with daptomycin.
Antimicrobial agents and chemotherapy - 1 Jun 2001
Silverman J A, Oliver N, Andrew T, Li T
Abstract excerpt
We studied the in vitro emergence of resistance to daptomycin using three methods: spontaneous resistance incidence, serial passage in the presence of increasing drug concentrations, and chemical mutagenesis. No spontaneously resistant mutants were obtained for any organism tested (<10(-10) for Staphylococcus aureus, <10(-9) for Staphylococcus epidermidis, <10(-9) for Enterococcus faecalis, <10(-9) for...
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