Article

Acquisition of daptomycin resistance in patients results in decreased virulence in <i>Drosophila</i>

2024-10-07

Abstract excerpt

Staphylococcus aureus can acquire antimicrobial resistance which in turn may affect its pathogenic potential. Using a panel of paired clinical isolates collected before and after daptomycin resistance acquisition, most frequently through single mprF mutation, we show a relationship between increasing daptomycin minimum inhibitory concentration and reduced virulence in a Drosophila systemic infection model. Analy...

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Literature Corpus work: 686d6615-a7e2-5f22-9e21-265d0105657c
DOI: 10.1101/2024.10.07.616954

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