Article
Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue.
PloS one - 1 Jan 2011
Devine Michael J, Kaganovich Alice, Ryten Mina, Mamais Adamantios, Trabzuni Daniah, Manzoni Claudia, McGoldrick Philip, Chan Diane, Dillman Allissa, Zerle Julia, Horan Susannah, Taanman Jan-Willem, Hardy John, Marti-Masso Jose-Felix, Healy Daniel, Healey Daniel, Schapira Anthony H, Wolozin Benjamin, Bandopadhyay Rina, Cookson Mark R, van der Brug Marcel P, Lewis Patrick A
Abstract excerpt
Point mutations in LRRK2 cause autosomal dominant Parkinson's disease. Despite extensive efforts to determine the mechanism of cell death in patients with LRRK2 mutations, the aetiology of LRRK2 PD is not well understood. To examine possible alterations in gene expression linked to the presence of LRRK2 mutations, we carried out a case versus control analysis of global gene expression in three systems:...
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