Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Scrapie-infected transgenic mice expressing a laminin receptor decoy mutant reveal a prolonged incubation time associated with low levels of PrPres.

Journal of molecular biology - 15 May 2009

Pflanz Heike, Vana Karen, Mitteregger Gerda, Renner-Müller Ingrid, Pace Claudia, Küchenhoff Helmut, Kretzschmar Hans A, Wolf Eckhard, Weiss Stefan

Abstract excerpt

The 37-kDa/67-kDa laminin receptor (LRP/LR) was identified as a cell surface receptor for prion proteins. The laminin receptor mutant LRP102-295::FLAG interfered with PrP(Sc) propagation in murine neuronal cells presumably acting as a decoy in a transdominant negative fashion by trapping PrP molecules in the extracellular matrix. Here, we generated hemizygous transgenic mice expressing LRP102-295::FLAG in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Kaplan-Meier Estimate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Prions

Share to Recombinant Fusion Proteins

Share to Scrapie

Share to Spleen

Source

Identifiers

PMID: 19324055
DOI: 10.1016/j.jmb.2009.03.045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Scrapie-infected transgenic mice expressing a laminin receptor decoy mutant reveal a prolonged incubation time associated with low levels of PrPres.PMID 19324055Read ↗

A trans-dominant negative 37kDa/67kDa laminin receptor mutant impairs PrP(Sc) propagation in scrapie-infected neuronal cells.Semantic proximity Read ↗

Interactions between PrPc and other ligands with the 37-kDa/67-kDa laminin receptorSemantic proximity Read ↗

Delivery of single-chain antibodies (scFvs) directed against the 37/67 kDa laminin receptor into mice via recombinant adeno-associated viral vectors for prion disease gene therapySemantic proximity Read ↗

LRP/LR as an alternative promising target in therapy of prion diseases, Alzheimer's disease and cancer.Semantic proximity Read ↗

Emerging roles of the cellular prion protein (PrPC) and 37/67 kDa laminin receptor (RPSA) interaction in cancer biologySemantic proximity Read ↗

Interaction of Doppel with the full-length laminin receptor precursor protein.Semantic proximity Read ↗

Ligands binding to the cellular prion protein induce its protective proteolytic release with therapeutic potential in neurodegenerative proteinopathiesSemantic proximity Read ↗

Cell surface accumulation of a truncated transmembrane prion protein in Gerstmann-Straussler-Scheinker disease P102L.Semantic proximity Read ↗

Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions.Semantic proximity Read ↗

Looking into laminin receptor: critical discussion regarding the non‐integrin 37/67‐<scp>kDa</scp>laminin receptor/<scp>RPSA</scp>proteinSemantic proximity Read ↗

An Amino Acid Substitution Found in Animals with Low Susceptibility to Prion Diseases Confers a Protective Dominant-Negative Effect in Prion-Infected Transgenic Mice.Semantic proximity Read ↗

An inherited prion disease with a PrP P105L mutationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.