Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofol.

doi:10.1016/j.neuroscience.2015.03.034

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Article

Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofol.

Neuroscience - 25 Jun 2015

Naito A, Muchhala K H, Trang J, Asatryan L, Trudell J R, Homanics G E, Alkana R L, Davies D L

Abstract excerpt

We recently developed ultra-sensitive ethanol receptors (USERs) as a novel tool for investigation of single receptor subunit populations sensitized to extremely low ethanol concentrations that do not affect other receptors in the nervous system. To this end, we found that mutations within the extracellular Loop 2 region of glycine receptors (GlyRs) and γ-aminobutyric acid type A receptors (GABAARs) can...

Topics

Animals
Biophysics
Central Nervous System Depressants
Dose-Response Relationship, Drug
Electric Stimulation
Ethanol
Extracellular Space
Hypnotics and Sedatives
Isoflurane
Lidocaine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Potentials

Mutation

Oocytes

Patch-Clamp Techniques

Propofol

Receptors, Glycine

Xenopus

Source

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Identifiers

PMID: 25827497
DOI: 10.1016/j.neuroscience.2015.03.034
PMCID: PMC4428915

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Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofol.PMID 25827497Read ↗

Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity.Semantic proximity Read ↗

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