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Article

A conserved tyrosine in the beta2 subunit M4 segment is a determinant of gamma-aminobutyric acid type A receptor sensitivity to propofol.

Anesthesiology - 1 Sept 2007

Richardson James E, Garcia Paul S, O'Toole Kate K, Derry Jason M C, Bell Shannon V, Jenkins Andrew

Abstract excerpt

BACKGROUND: The gamma-aminobutyric acid type A receptor (GABAA-R) beta subunits are critical targets for the actions for several intravenous general anesthetics, but the precise nature of the anesthetic binding sites are unknown. In addition, little is known about the role the fourth transmembrane (M4) segment of the receptor plays in receptor function. The aim of this study was to better define the propofol...

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Source

Identifiers

PMID: 17721243
DOI: 10.1097/01.anes.0000278875.36639.2c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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