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Article

Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity.

The Journal of biological chemistry - 2 Oct 2009

Perkins Daya I, Trudell James R, Crawford Daniel K, Asatryan Liana, Alkana Ronald L, Davies Daryl L

Abstract excerpt

The present study tests the hypothesis that the structure of extracellular domain Loop 2 can markedly affect ethanol sensitivity in glycine receptors (GlyRs) and gamma-aminobutyric acid type A receptors (GABA(A)Rs). To test this, we mutated Loop 2 in the alpha1 subunit of GlyRs and in the gamma subunit of alpha1beta2gamma2GABA(A)Rs and measured the sensitivity of wild type and mutant receptors expressed in...

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Identifiers

PMID: 19656948
DOI: 10.1074/jbc.M109.023598
PMCID: PMC2785658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity.PMID 19656948Read ↗

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