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Endogenous retrovirus induces leukemia in a xenograft mouse model for primary myelofibrosis

27 May 2014

Abstract excerpt

The compound immunodeficiencies in nonobese diabetic (NOD) inbred mice homozygous for the Prkdc(scid) and Il2rg(null) alleles (NSG mice) permit engraftment of a wide-range of primary human cells, enabling sophisticated modeling of human disease. In studies designed to define neoplastic stem cells of primary myelofibrosis (PMF), a myeloproliferative neoplasm characterized by profound disruption of the...

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PMID: 24912157
DOI: 10.1073/pnas.1401215111

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