Article
CD1d expression level in tumor cells is an important determinant for anti-tumor immunity by natural killer T cells.
Leukemia & lymphoma - 1 Oct 2006
Haraguchi Kyoko, Takahashi Tsuyoshi, Nakahara Fumio, Matsumoto Akihiko, Kurokawa Mineo, Ogawa Seishi, Oda Hideaki, Hirai Hisamaru, Chiba Shigeru
Abstract excerpt
Invariant natural killer T (iNKT) cells are thought to regulate anti-tumor immunity. Human iNKT (i.e. Valpha24+ NKT) cells have been reported to recognize CD1d on target cells and show cytotoxicity directly on the target cells in vitro. However, the anti-tumor effect of mouse iNKT (i.e. Valpha14+ NKT) cells has been repeatedly reported to be dependent on the activity of natural killer (NK) cells via...
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