Article
Identification of hepatitis C virus NS5A inhibitors.
Journal of virology - 1 Jan 2010
Lemm Julie A, O'Boyle Donald, Liu Mengping, Nower Peter T, Colonno Richard, Deshpande Milind S, Snyder Lawrence B, Martin Scott W, St Laurent Denis R, Serrano-Wu Michael H, Romine Jeffrey L, Meanwell Nicholas A, Gao Min
Abstract excerpt
Using a cell-based replicon screen, we identified a class of compounds with a thiazolidinone core structure as inhibitors of hepatitis C virus (HCV) replication. The concentration of one such compound, BMS-824, that resulted in a 50% inhibition of HCV replicon replication was approximately 5 nM, with a therapeutic index of >10,000. The compound showed good specificity for HCV, as it was not active against several...
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