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Article

A novel mutant-enriched liquidchip technology for the qualitative detection of somatic mutations in KRAS gene from both serum and tissue samples.

Clinical chemistry and laboratory medicine - 1 Aug 2010

Wu Shiyang, Zhu Zeyao, He Jiaying, Luo Xiaodi, Xu Jiasen, Ren-Heidenreich Lifen

Abstract excerpt

BACKGROUND: Somatic mutations in the KRAS gene have been reported to confer drug resistance to epidermal growth factor receptor tyrosine kinase inhibitors and some monoclonal antibodies. However, current DNA mutation detection technologies are primarily DNA sequencing-based and not high throughput, nor sensitive enough to meet clinical needs. METHODS: A mutant-enriched PCR method was designed by introducing a...

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Identifiers

PMID: 20482381
DOI: 10.1515/CCLM.2010.227

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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