Article
Genome-wide association study of blood lead shows multiple associations near ALAD.
Human molecular genetics - 1 Jul 2015
Warrington Nicole M, Zhu Gu, Dy Veronica, Heath Andrew C, Madden Pamela A F, Hemani Gibran, Kemp John P, Mcmahon George, St Pourcain Beate, Timpson Nicholas J, Taylor Caroline M, Golding Jean, Lawlor Debbie A, Steer Colin, Montgomery Grant W, Martin Nicholas G, Davey Smith George, Evans David M, Whitfield John B
Abstract excerpt
Exposure to high levels of environmental lead, or biomarker evidence of high body lead content, is associated with anaemia, developmental and neurological deficits in children, and increased mortality in adults. Adverse effects of lead still occur despite substantial reduction in environmental exposure. There is genetic variation between individuals in blood lead concentration but the polymorphisms contributing...
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