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Article

Influence of the common human delta-aminolevulinate dehydratase polymorphism on lead body burden.

Environmental health perspectives - 1 Sept 1994

Wetmur J G

Abstract excerpt

delta-Aminolevulinate dehydratase (ALAD) is the second enzyme in the heme biosynthesis pathway. ALAD is a zinc metalloenzyme, and its inhibition by lead substitution for zinc is one of the most sensitive indicators of blood-lead accumulation, a measure of recent lead exposure. Stoichiometry calculations indicate that a significant portion of blood lead is stored in ALAD. Human ALAD exhibits a charge polymorphism,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 7843101
DOI: 10.1289/ehp.94102s3215
PMCID: PMC1567421

Genes

ALAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Influence of the common human delta-aminolevulinate dehydratase polymorphism on lead body burden.PMID 7843101Read ↗

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delta-Aminolevulinate dehydratase (ALAD) porphyria: the first case in North America with two novel ALAD mutations.Semantic proximity Read ↗

Modifying effects of δ-Aminolevulinate dehydratase polymorphism on blood lead levels and ALAD activity.Semantic proximity Read ↗

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