Influence of the common human delta-aminolevulinate dehydratase polymorphism on lead body burden.

doi:10.1289/ehp.94102s3215

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Article

Influence of the common human delta-aminolevulinate dehydratase polymorphism on lead body burden.

Environmental health perspectives - 1 Sept 1994

Wetmur J G

Abstract excerpt

delta-Aminolevulinate dehydratase (ALAD) is the second enzyme in the heme biosynthesis pathway. ALAD is a zinc metalloenzyme, and its inhibition by lead substitution for zinc is one of the most sensitive indicators of blood-lead accumulation, a measure of recent lead exposure. Stoichiometry calcu...

Topics

Animals
Base Sequence
Body Burden
Clinical Trials as Topic
Humans
Lead
Molecular Sequence Data
Phenotype
Polymorphism, Genetic
Porphobilinogen Synthase

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