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Article

NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis.

Nature genetics - 1 Oct 1998

Chen Z F, Paquette A J, Anderson D J

Abstract excerpt

The neuron-restrictive silencer factor NRSF (also known as REST and XBR) can silence transcription from neuronal promoters in non-neuronal cell lines, but its function during normal development is unknown. In mice, a targeted mutation of Rest, the gene encoding NRSF, caused derepression of neuron-specific tubulin in a subset of non-neural tissues and embryonic lethality. Mosaic inhibition of NRSF in chicken...

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Source

Identifiers

PMID: 9771705
DOI: 10.1038/2431

Genes

REST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis.PMID 9771705Read ↗

Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes.Semantic proximity Read ↗

NRSF/REST levels are decreased in cholangiocellular carcinoma but not hepatocellular carcinoma compared with normal liver tissues: A tissue microarray studySemantic proximity Read ↗

Absence of binding activity of neuron-restrictive silencer factor is necessary, but not sufficient for transcription of NMDA receptor subunit type 1 in neuronal cells.Semantic proximity Read ↗

Repressor element-1 silencing transcription/neuron-restrictive silencer factor is required for neural sodium channel expression during development of Xenopus.Semantic proximity Read ↗

Regulation of human tyrosine hydroxylase gene by neuron-restrictive silencer factor.Semantic proximity Read ↗

TRF2-Mediated Stabilization of hREST4 Is Critical for the Differentiation and Maintenance of Neural ProgenitorsSemantic proximity Read ↗

Reciprocal actions of REST and a microRNA promote neuronal identity.Semantic proximity Read ↗

Transcriptional regulation of the neuropeptide VGF by the neuron-restrictive silencer factor/neuron-restrictive silencer element.Semantic proximity Read ↗

Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines.Semantic proximity Read ↗

MiR-375 is Essential for Human Spinal Motor Neuron Development and May Be Involved in Motor Neuron DegenerationSemantic proximity Read ↗

Relaxation of glycine receptor and onconeural gene transcription control in NRSF deficient small cell lung cancer cell lines.Semantic proximity Read ↗

NRSF/REST neuronal deficient mice are more vulnerable to the neurotoxin MPTP.Semantic proximity Read ↗

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