Article
NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis.
Nature genetics - 1 Oct 1998
Chen Z F, Paquette A J, Anderson D J
Abstract excerpt
The neuron-restrictive silencer factor NRSF (also known as REST and XBR) can silence transcription from neuronal promoters in non-neuronal cell lines, but its function during normal development is unknown. In mice, a targeted mutation of Rest, the gene encoding NRSF, caused derepression of neuron...
Topics
- Amino Acid Sequence
- Animals
- Chick Embryo
- DNA-Binding Proteins
- Gene Expression Regulation, Developmental
- Mice
- Molecular Sequence Data
- Morphogenesis
- Mosaicism
- Mutation
- Nervous System
- Neurons
- Repressor Proteins
- Transcription Factors
- Tubulin
- Zinc Fingers