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Article

E2F1 enhances glycolysis through suppressing Sirt6 transcription in cancer cells.

Oncotarget - 10 May 2015

Wu Minghui, Seto Edward, Zhang Jingsong

Abstract excerpt

The fast proliferation of cancer cells requires reprogramming of its energy metabolism with aerobic glycolysis as a major energy source. Sirt6, a class III histone deacetylase, has been shown to down regulate glycolysis by inhibiting the expression of several key glycolytic genes. Based on the published study on the metabolic phenotype of E2F1 -/- mice and SIRT6 -/- mice, we hypothesize that E2F1 enhances...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25816777
DOI: 10.18632/oncotarget.3594
PMCID: PMC4484454

Genes

HDAC1
SIRT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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