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GATA4 Is a Key Regulator of Steroidogenesis and Glycolysis in Mouse Leydig Cells

10 Feb 2015

Abstract excerpt

Transcription factor GATA4 is expressed in somatic cells of the mammalian testis. Gene targeting studies in mice have shown that GATA4 is essential for proper differentiation and function of Sertoli cells. The role of GATA4 in Leydig cell development, however, remains controversial, because targeted mutagenesis experiments in mice have not shown a consistent phenotype, possibly due to context-dependent effects or...

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PMID: 25668067
DOI: 10.1210/en.2014-1931

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