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Article

SIRT5 promotes cell proliferation and invasion in hepatocellular carcinoma by targeting E2F1

25 Oct 2017

Abstract excerpt

Sirtuin 5 (SIRT5) is a member of the NAD+‑dependent class III protein deacetylases. Although it is known that SIRT5 deacetylates and activates urate oxidase in the liver mitochondria of mice, the mechanism of SIRT5 in the proliferation of hepatocellular carcinoma (HCC) remains to be fully elucidated. The present study investigated the expression and functional significance of SIRT5 in HCC, and examined the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29115436
DOI: 10.3892/mmr.2017.7875

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