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SIRT6 deficiency impairs the deacetylation and ubiquitination of UHRF1 to strengthen glycolysis and lactate secretion in bladder cancer

21 Dec 2024

Abstract excerpt

BACKGROUND: Aberrant interplay between epigenetic reprogramming and metabolic rewiring events contributes to bladder cancer progression and metastasis. How the deacetylase Sirtuin-6 (SIRT6) regulates glycolysis and lactate secretion in bladder cancer remains poorly defined. We thus aimed to study the biological functions of SIRT6 in bladder cancer. METHODS: Bioinformatic analysis was used to study the prognostic...

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PMID: 39709438
DOI: 10.1186/s13578-024-01333-2

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