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Macrophages from naked mole-rat possess distinct immunometabolic signatures upon polarization.

Frontiers in immunology - 1 Jan 2023

Gorshkova Ekaterina A, Gubernatorova Ekaterina O, Dvorianinova Ekaterina M, Yurakova Taisiya R, Marey Maria V, Averina Olga A, Holtze Susanne, Hildebrandt Thomas B, Dmitriev Alexey A, Drutskaya Marina S, Vyssokikh Mikhail Yu, Nedospasov Sergei A

Abstract excerpt

The naked mole-rat (NMR) is a unique long-lived rodent which is highly resistant to age-associated disorders and cancer. The immune system of NMR possesses a distinct cellular composition with the prevalence of myeloid cells. Thus, the detailed phenotypical and functional assessment of NMR myeloid cell compartment may uncover novel mechanisms of immunoregulation and healthy aging. In this study gene expression...

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PMID: 37153552
DOI: 10.3389/fimmu.2023.1172467
PMCID: PMC10154529

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