Article
Protease activity of PprI facilitates DNA damage response: Mn2+-dependence and substrate sequence-specificity of the proteolytic reaction.
PloS one - 1 Jan 2015
Wang Yunguang, Xu Qiang, Lu Huiming, Lin Lin, Wang Liangyan, Xu Hong, Cui Xianyan, Zhang Hui, Li Tingting, Hua Yuejin
Abstract excerpt
The extremophilic bacterium Deinococcus radiodurans exhibits an extraordinary resistance to ionizing radiation. Previous studies established that a protein named PprI, which exists only in the Deinococcus-Thermus family, acts as a general switch to orchestrate the expression of a number of DNA damage response (DDR) proteins involved in cellular radio-resistance. Here we show that the regulatory mechanism of PprI...
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