Article
Conservation and diversity of the IrrE/DdrO-controlled radiation response in radiation-resistant Deinococcus bacteria.
MicrobiologyOpen - 1 Aug 2017
Blanchard Laurence, Guérin Philippe, Roche David, Cruveiller Stéphane, Pignol David, Vallenet David, Armengaud Jean, de Groot Arjan
Abstract excerpt
The extreme radiation resistance of Deinococcus bacteria requires the radiation-stimulated cleavage of protein DdrO by a specific metalloprotease called IrrE. DdrO is the repressor of a predicted radiation/desiccation response (RDR) regulon, composed of radiation-induced genes having a conserved DNA motif (RDRM) in their promoter regions. Here, we showed that addition of zinc ions to purified apo-IrrE, and short...
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