Article
Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF.
The Journal of clinical investigation - 1 Sept 2008
Yago Tadayuki, Lou Jizhong, Wu Tao, Yang Jun, Miner Jonathan J, Coburn Leslie, López José A, Cruz Miguel A, Dong Jing-Fei, McIntire Larry V, McEver Rodger P, Zhu Cheng
Abstract excerpt
Arterial blood flow enhances glycoprotein Ibalpha (GPIbalpha) binding to vWF, which initiates platelet adhesion to injured vessels. Mutations in the vWF A1 domain that cause type 2B von Willebrand disease (vWD) reduce the flow requirement for adhesion. Here we show that increasing force on GPIbalpha/vWF bonds first prolonged ("catch") and then shortened ("slip") bond lifetimes. Two type 2B vWD A1 domain mutants,...
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