Article
Structural basis of von Willebrand factor activation by the snake toxin botrocetin.
Structure (London, England : 1993) - 1 Jul 2002
Fukuda Koichi, Doggett Teresa A, Bankston Laurie A, Cruz Miguel A, Diacovo Thomas G, Liddington Robert C
Abstract excerpt
The A1 domain of von Willebrand factor (vWF) mediates platelet adhesion to sites of vascular injury by binding to the platelet receptor glycoprotein Ib (GpIb), an interaction that is regulated by hydrodynamic shear forces. The GpIb binding surface of A1 is distinct from a regulatory region, suggesting that ligand binding is controlled allosterically. Here we report the crystal structures of the "gain-of-function"...
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