Article

Magnetic Tweezers Experiments Reveal Increased Mechanical Sensitivity of the F2561Y Mutant in Von Willebrand Factor

2026-06-06

Abstract excerpt

The large glycoprotein von Willebrand factor (VWF) is essential for primary hemostasis. By sensing hydrodynamic forces in the bloodstream, VWF elongates under elevated shear, increasing its adhesiveness to platelets. This mechanosensitive behavior arises from its multidomain architecture, where distinct structural elements respond at different force scales. The stem, formed by interactions between C-domains of adj...

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Literature Corpus work: 947f7a0c-2707-5522-9b0f-0e598c2c87d9
DOI: 10.64898/2026.06.05.730321

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