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Article

Structural basis of regulation of von Willebrand factor binding to glycoprotein Ib.

The Journal of biological chemistry - 28 Feb 2014

Blenner Mark A, Dong Xianchi, Springer Timothy A

Abstract excerpt

Activation by elongational flow of von Willebrand factor (VWF) is critical for primary hemostasis. Mutations causing type 2B von Willebrand disease (VWD), platelet-type VWD (PT-VWD), and tensile force each increase affinity of the VWF A1 domain and platelet glycoprotein Ibα (GPIbα) for one another; however, the structural basis for these observations remains elusive. Directed evolution was used to discover a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Platelet Glycoprotein GPIb-IX Complex

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Source

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Identifiers

PMID: 24391089
DOI: 10.1074/jbc.M113.511220
PMCID: PMC3937634

Genes

VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural basis of regulation of von Willebrand factor binding to glycoprotein Ib.PMID 24391089Read ↗

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