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Article

Activity-dependent FMRP requirements in development of the neural circuitry of learning and memory.

Development (Cambridge, England) - 1 Apr 2015

Doll Caleb A, Broadie Kendal

Abstract excerpt

The activity-dependent refinement of neural circuit connectivity during critical periods of brain development is essential for optimized behavioral performance. We hypothesize that this mechanism is defective in fragile X syndrome (FXS), the leading heritable cause of intellectual disability and autism spectrum disorders. Here, we use optogenetic tools in the Drosophila FXS disease model to test...

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Identifiers

PMID: 25804740
DOI: 10.1242/dev.117127
PMCID: PMC4378248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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