Article
Signaling network assessment of mutations and copy number variations predict breast cancer subtype-specific drug targets.
Cell reports - 17 Oct 2013
Zaman Naif, Li Lei, Jaramillo Maria Luz, Sun Zhanpeng, Tibiche Chabane, Banville Myriam, Collins Catherine, Trifiro Mark, Paliouras Miltiadis, Nantel Andre, O'Connor-McCourt Maureen, Wang Edwin
Abstract excerpt
Individual cancer cells carry a bewildering number of distinct genomic alterations (e.g., copy number variations and mutations), making it a challenge to uncover genomic-driven mechanisms governing tumorigenesis. Here, we performed exome sequencing on several breast cancer cell lines that represent two subtypes, luminal and basal. We integrated these sequencing data and functional RNAi screening data (for the...
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