Article
NCAN Cross-Disorder Risk Variant Is Associated With Limbic Gray Matter Deficits in Healthy Subjects and Major Depression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2015
Dannlowski Udo, Kugel Harald, Grotegerd Dominik, Redlich Ronny, Suchy Janina, Opel Nils, Suslow Thomas, Konrad Carsten, Ohrmann Patricia, Bauer Jochen, Kircher Tilo, Krug Axel, Jansen Andreas, Baune Bernhard T, Heindel Walter, Domschke Katharina, Forstner Andreas J, Nöthen Markus M, Treutlein Jens, Arolt Volker, Hohoff Christa, Rietschel Marcella, Witt Stephanie H
Abstract excerpt
Genome-wide association studies have reported an association between NCAN rs1064395 genotype and bipolar disorder. This association was later extended to schizophrenia and major depression. However, the neurobiological underpinnings of these associations are poorly understood. NCAN is implicated in neuronal plasticity and expressed in subcortical brain areas, such as the amygdala and hippocampus, which are...
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