A genome-wide supported psychiatric risk variant in NCAN influences brain function and cognitive performance in healthy subjects.

doi:10.1002/hbm.22635

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Article

A genome-wide supported psychiatric risk variant in NCAN influences brain function and cognitive performance in healthy subjects.

Human brain mapping - 1 Jan 2015

Raum Heidelore, Dietsche Bruno, Nagels Arne, Witt Stephanie H, Rietschel Marcella, Kircher Tilo, Krug Axel

Abstract excerpt

The A allele of the single nucleotide polymorphism (SNP) rs1064395 in the NCAN gene has recently been identified as a susceptibility factor for bipolar disorder and schizophrenia. NCAN encodes neurocan, a brain-specific chondroitin sulfate proteoglycan that is thought to influence neuronal adhesion and migration. Several lines of research suggest an impact of NCAN on neurocognitive functioning. In the present...

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Identifiers

PMID: 25220293
DOI: 10.1002/hbm.22635
PMCID: PMC6869521

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NCAN

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