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Article

Soma-localized Rab39 inhibits synaptic autophagy by controlling trafficking of Atg9 vesicles

21 Aug 2025

Abstract excerpt

Presynaptic terminals can be located far from the neuronal cell body and are thought to independently regulate protein and organelle turnover. Autophagy is a critical process for maintaining proteostasis, and its synaptic dysregulation is associated with neurodegenerative diseases. In this work, we report a soma-centered mechanism that regulates autophagy-controlled protein turnover at distant presynaptic...

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PMID: 40841711
DOI: 10.1038/s44318-025-00536-8

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