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Article

ALS2 regulates endosomal trafficking, postsynaptic development, and neuronal survival.

The Journal of cell biology - 3 May 2021

Kim Joohyung, Kim Sungdae, Nahm Minyeop, Li Tsai-Ning, Lin Hsin-Chieh, Kim Yeongjin David, Lee Jihye, Yao Chi-Kuang, Lee Seungbok

Abstract excerpt

Mutations in the human ALS2 gene cause recessive juvenile-onset amyotrophic lateral sclerosis and related motor neuron diseases. Although the ALS2 protein has been identified as a guanine-nucleotide exchange factor for the small GTPase Rab5, its physiological roles remain largely unknown. Here, we demonstrate that the Drosophila homologue of ALS2 (dALS2) promotes postsynaptic development by activating the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33683284
DOI: 10.1083/jcb.202007112
PMCID: PMC7944400

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