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Article

Lineage Tracking for Probing Heritable Phenotypes at Single-Cell Resolution.

PloS one - 1 Jan 2016

Cottinet Denis, Condamine Florence, Bremond Nicolas, Griffiths Andrew D, Rainey Paul B, de Visser J Arjan G M, Baudry Jean, Bibette Jérôme

Abstract excerpt

Determining the phenotype and genotype of single cells is central to understand microbial evolution. DNA sequencing technologies allow the detection of mutants at high resolution, but similar approaches for phenotypic analyses are still lacking. We show that a drop-based millifluidic system enables the detection of heritable phenotypic changes in evolving bacterial populations. At time intervals, cells were...

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Identifiers

PMID: 27077662
DOI: 10.1371/journal.pone.0152395
PMCID: PMC4831777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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