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Article

GNAS Is frequently mutated in a specific subgroup of intraductal papillary neoplasms of the bile duct.

The American journal of surgical pathology - 1 Dec 2013

Tsai Jia-Huei, Yuan Ray-Hwang, Chen Yu-Ling, Liau Jau-Yu, Jeng Yung-Ming

Abstract excerpt

Intraductal papillary neoplasms of the bile duct (IPN-Bs) share clinicopathologic features with intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. Approximately two thirds of IPMNs have activating point mutations of GNAS at codon 201. The role of GNAS mutation is unclear in IPN-B. In this study, we evaluated 41 patients diagnosed with IPN-B for clinicopathologic characteristics and follow-up...

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Share to Bile Duct Neoplasms
Share to Bile Ducts, Intrahepatic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Papillary

Share to Chromogranins

Share to GTP-Binding Protein alpha Subunits, Gs

Share to Kaplan-Meier Estimate

Share to Proto-Oncogene Proteins p21(ras)

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Source

Identifiers

PMID: 24061513
DOI: 10.1097/PAS.0b013e3182986bb5

Genes

GNAS
KRAS
CDX2
MUC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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GNAS Is frequently mutated in a specific subgroup of intraductal papillary neoplasms of the bile duct.PMID 24061513Read ↗

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Intraductal Papillary Neoplasm of Bile Duct: Updated Clinicopathological Characteristics and Molecular and Genetic AlterationsSemantic proximity Read ↗

GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct.Semantic proximity Read ↗

Intraductal papillary neoplasms of the bile duct consist of two distinct types specifically associated with clinicopathological features and molecular phenotypes.Semantic proximity Read ↗

GNAS and KRAS mutational analyses of intraductal papillary neoplasms of the pancreas and bile duct developing in the same individual: A case report.Semantic proximity Read ↗

Activating mutations of GNAS and KRAS in cystic fluid can help detect intraductal papillary mucinous neoplasms of the pancreas.Semantic proximity Read ↗

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