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Article

CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Apr 2006

Arango Margarita, Holbert Sébastien, Zala Dania, Brouillet Emmanuel, Pearson James, Régulier Etienne, Thakur Ashwani Kumar, Aebischer Patrick, Wetzel Ronald, Déglon Nicole, Néri Christian

Abstract excerpt

Transcriptional dysregulation caused by expanded polyglutamines (polyGlns) in huntingtin (htt) may be central to cell-autonomous mechanisms for neuronal cell death in Huntington's disease (HD) pathogenesis. We hypothesized that these mechanisms may involve the dysfunction of the transcriptional regulator CA150, a putative modifier of onset age in HD, because it binds to htt and accumulates in an HD...

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Identifiers

PMID: 16641246
DOI: 10.1523/JNEUROSCI.5409-05.2006
PMCID: PMC6674076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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