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Article

A chemical genetics approach for the functional assessment of novel cancer genes.

Cancer research - 15 May 2015

Zhou Qianhe, Derti Adnan, Ruddy David, Rakiec Daniel, Kao Iris, Lira Michelle, Gibaja Veronica, Chan HoMan, Yang Yi, Min Junxia, Schlabach Michael R, Stegmeier Frank

Abstract excerpt

Assessing the functional significance of novel putative oncogenes remains a significant challenge given the limitations of current loss-of-function tools. Here, we describe a method that employs TALEN or CRISPR/Cas9-mediated knock-in of inducible degron tags (Degron-KI) that provides a versatile...

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PMID: 25788694
DOI: 10.1158/0008-5472.CAN-14-2930

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25788694-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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